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KMID : 0061119820100000078
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Bulletin of the Clinical Research Institute
1982 Volume.10 No. 0 p.78 ~ p.78
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Dose-Related Muscle Relaxation by d-Tubocurarine During Halothane Anesthesia
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Suh Jae-Hyun
chon Se-Ung
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Abstract
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There are many reports that d-tubocurarine has marked species and individual variations in their response to muscle relaxation. Therefore dose-related neuromuscular blocking effect of d-tubocurarine was studied in anesthetized´ patients.
Eighty adult patients were studied during halothane-N_(2)O-O_(2) anesthesia for various surgery. Forty patients received a single intravenous d-tubocurarine 0.1 ㎎/㎏ (Group A) and the other forty patients received a single intravenous d-tubocurarine 0.2 ㎎/㎏ (Group B) after the succinylcholine effect was abolished in both groups.
The data were plotted as onset time of twitch depression and percentage depression of twitch height, and recovery time of "Train of four response were analyzed in each group.
The results were as follows.
1. In d-tubocurarine 0.1 ㎎/㎏ group the effect of d-tubocurarine was variable, ranging from no effect on twitch tension to abolished it. Mean maximal twitch depression was 59.4%. Recovery index which showed more than 75% twitch depression was 39.9 minutes.
2. In d-tubocurarine 0.2 ㎎/㎏ group; the effect of d-tubocurarine was obtained consistent and solid neuromuscular relaxation. Mean maximal twitch depression was 95.2%. Recovery index was 58.1 minutes.
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